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| Product Name: |
oleanolic acid (Aralia chinensis Extract)
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| Supply Ability: |
100000kg |
| Related proudcts |
oleanolic acid, aralia chinensis ext, |
| Specifications |
98% |
| Price Term: |
CIF |
| Port of loading: |
Any port according to your requirements |
| Minimum Order |
10KG |
| Unit Price: |
0 |
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Aralia chinensis Extract
Active Ingredient: Oleanolic acid oleanolic acid (Aralia chinensis Extract)Specification: 98%
Test Method UV-VIS
oleanolic acid Herb Source
Olea europaea L. Swertia mileensis T.N. Ho et W. L. Shi Ligustrum lucidum Ait
oleanolic acid Synonyms
Oleanol Caryophyllin
oleanolic acid Molecular Formula and Molecular Weight
C30H48O3¡ê»456.71
oleanolic acid Melting Point
308¡ãC-310¡ãC
oleanolic acid Solubility
Insoluble in water¡ê¬Sol in ether¡ê¬acetone¡ê¬chloroform and ethanol
oleanolic acid Brief
Structural Class¡êoTriterpene Appearance¡êoWhite crystal
oleanolic acid Pharmacology
Protect liver and depress enzyme¡ê¬ Anti-inflammation, Diuretic,Anti-cancer
Two triterpene acids, oleanolic acid (OA) and ursolic acid (UA), purified components from several Botanical drugs with known antitumor activity such as, were examined for their ability and possible pathway on inhibiting the tumor growth of hepG2 cells. Cells were treated with OA and UA with doses of 100 and 200 ug/ml for 12, 24 and 36 hrs, respectively. The changes of DNA fragmentation, apoptotic bodies, DNA synthesis and the expression of cell cycle related genes were investigated after various treatments. Decrease of DNA synthesis in cells treated with both OA and UA was obviously observed at these doses for 24 and 36 hrs by using BrdU staining method. Total RNA were purified with RNA Zol B reagent and the first stranded cDNA were synthesized by AMV transcriptase. Semiquantitation of the cDNA was performed by primer dropping method. Both mRNA and protein of the CDK inhibitor of INK4 family which specifically inhibits CDK4/6 activity and then reduces the phosphorylation of RB, p-15INK4b, in hepG2 cells were greatly induced by OA and UA. However, the expression of another member in this family, p-16INK4a, was not significantly induced. Other CDK inhibitors such as p-21CIP, p-27KIP and cell cycle related genes were not induced after various OA and UA treatments. The DNA fragmentatio |
| Company: |
Changsha Organic Herb Inc
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| Contact: |
Ms. Sally Cheng |
| Address: |
A301 International Enterprice Center, No. 188, Huanbao Middle Road, Yuhua District, Changsha City, Hunan Province, P.R. China |
| Postcode: |
410000 |
| Tel: |
8673182739226 |
| Fax: |
8673182739211 |
| E-mail: |
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